SCC

• in patients with cervical carcinoma. In this case, it can serve for early detection of relapses, the presence of residual disease and monitoring the effect of therapy. Despite the fact that it has a specificity of about 90% and a sensitivity of 70-80% in squamous cell carcinoma, its independent use as a screening marker for the detection of a primary tumor is not recommended.
• can be used as a second-line marker in patients with non-small cell lung cancer (after Cyfra 21-1)
• in esophageal carcinoma
• squamous cell carcinoma of the anus
• carcinomas in the area of the head (tongue) and neck

Slightly increased values (up to 50%) can be observed in some cases with:

• liver cirrhosis
• carcinomas of the gastrointestinal tract, including adenocarcinomas pancreatitis
• kidney failure
• endometriosis and other gynecological diseases in about 37% in patients with chronic lung diseases such as COPD
• psoriasis, eczema, pemphigus

The SCC antigen is normally found in sweat, saliva and other bodily secretions. Contamination of the test material with them (e.g. salivary aerosol) can therefore cause readings of falsely elevated values.